Jarrow Formulas, Natural SAM-e (S-Adenosyl-L-Methionine) 400, 400 mg, 30 Enteric-Coated Tablets

Economize 30%
Jarrow FormulasSKU: 1520020

$30.45 $43.50


  • Individually Blister-Packed
  • Enteric-Coated
  • Central biochemical building block
  • Body’s primary methyl donor
  • Made Naturally By Fermentation

Jarrow Formulas SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAM-e, the highest active level available. SAM-e has been clinically shown to have the following benefits: Joint Strength SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAM-E metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body's endogenous antioxidant network and important for liver function, including phase II detoxification. EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resist stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.

Suggested Use

Take 1 tablet per day on an empty stomach, or as directed by your qualified health care professional.


Individual using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRI) and MAO Inhibitors should consult a physician before using this product. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use. Jarrow Formulas Sam-e 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken. Store in a cool, dry place. Keep out of the reach of children.

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